GAMMAGARD LIQUID is indicated as a maintenance therapy to improve muscle strength and disability in adult patients with Multifocal Motor Neuropathy (MMN). GAMMAGARD LIQUID for MMN is for intravenous use only.
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Dosing & Infusion Rates for MMN
MMN = Multifocal Motor Neuropathy.
Dose and infusion rates for MMN1
When starting a patient on treatment with GAMMAGARD LIQUID, the correct dose and rate of administration is based on the treatment indication and the individual patient’s weight.
GAMMAGARD LIQUID is an Intravenous immune globulin (IVIG) for adult patients with multifocal motor neuropathy (MMN).
| IV Administration | |
|---|---|
| Dose | Dose range 0.5 to 2.4 grams/kg/month based on clinical response |
| Initial Rate of Infusion | 0.5 mL/kg/hr (0.8 mg/kg/min) |
| Maintenance Infusion Rate | Infusion rate may be increased if tolerated up to 5.4 mL/kg/hr (9 mg/kg/min) |
IVIG Dosing for MMN1
The dose of GAMMAGARD LIQUID may need to be adjusted to achieve the desired clinical response. In the clinical study for MMN treatment, the dose ranged from 0.5 to 2.4 g/kg/month.
While receiving GAMMAGARD LIQUID, 9% of patients in the clinical study experienced neurological decompensation that required an increase in dose. Accordingly, dose adjustment may be necessary to avoid worsening of muscle weakness in patients with MMN.
Dosing calculator
Dosing range | Calculated infusion rates†
500 to 2400 mg/kg (0.5 to 2.4 g/kg) per month based on clinical response
| Min(g) | Max(g) |
|---|---|
| 3 | 6 |
| Time | mL/hr |
| 0-.5hrs (mL/hr) | 5 |
| .5-1hr (mL/hr) | 10 |
| 1-1.5hrs (mL/hr) | 20 |
| 1.5-2hr (mL/hr) | 30 |
| 2-2.5hrs (mL/hr) | 40 |
| 2.5hrs - end of infusion (mL/hr) | 50 |
Healthcare professionals should determine the appropriate dose for each patient based on patient examination, characteristics, and medical judgment. MMN Dosing Calculator is a tool intended to help an HCP make informed decisions about dosing and not intended to make dosing recommendations.
*Weights have been rounded to the nearest pound; calculations based on this have also been rounded.
†GAMMAGARD LIQUID IV maintenance infusion rate may be increased every 30 minutes based on patient tolerability.
Additional Considerations
Ensure patients with preexisting renal insufficiency are not volume depleted; discontinue GAMMAGARD LIQUID if renal function deteriorates.1
For patients over 65 years of age or judged to be at risk for renal dysfunction or thrombotic events, administer GAMMAGARD LIQUID at the minimum infusion rate practicable.1
How is GAMMAGARD LIQUID manufactured?
Every step of the process, from collection to manufacturing and delivery, ensures reliable, well-controlled, and high safety margins.1
Reference:
- GAMMAGARD LIQUID [Immune Globulin Infusion (Human)] 10%. Prescribing Information. Takeda Pharmaceuticals U.S.A., Inc.; 2024.