About Primary Immunodeficiency1-4
Primary immunodeficiency (PI) is an umbrella term used to describe a group of more than 350 genetic disorders that can cause your immune system to not work like it should.
PI is a chronic disorder that causes your immune system to work improperly. This leads to increased chance of infections. And because the type and severity of infections can vary, diagnosing PI can be difficult.
PI can't be caught or spread. It's not contagious. Usually PI is inherited, which means it may run in families. Some types of PI may be caused by both genetic and environmental factors.
References: 1. Picard C, Gaspar HB, Al-Herz W, et al. International union of immunological societies: 2017 primary immunodeficiency diseases committee report on inborn errors of immunity. J Clin Immunol. 2018;38(1):96-128. 2. Blaese RM, Bonilla FA, Stiehm ER, Younger ME, eds. Patient & Family Handbook for Primary Immunodeficiency Diseases. 5th ed. Towson, MD: Immune Deficiency Foundation; 2013. 3. About Primary Immunodeficiencies. Immune Deficiency Foundation website. https://primaryimmune.org/about-primary-immunodeficiencies/. Accessed June 12, 2019. 4. de Vries E, Driessen G. Educational paper: primary immunodeficiencies in children: a diagnostic challenge. Eur J Pediatr. 2011;170(2):169-177.