What is GAMMAGARD LIQUID treatment?

GAMMAGARD LIQUID is a ready-to-use liquid medicine that contains immunoglobulin (Ig) antibodies, which protect the body against infection. These antibodies, collected from healthy people, replace the missing antibodies in PI patients.

GAMMAGARD LIQUID treatment is used to treat people 2 years and older with primary immunodeficiency (PI) diseases. There are many forms of PI. The most common types of PI result in an inability to make a very important type of protein called antibodies, which help the body fight off infections from bacteria or viruses. GAMMAGARD LIQUID is made from human plasma that is donated by healthy people. It may carry a risk of transmitting viruses.1

To learn more, visit our GAMMAGARD LIQUID section.

How is GAMMAGARD LIQUID treatment administered?

GAMMAGARD LIQUID treatment can be administered into a vein (intravenously or IV) or under the skin (subcutaneously or SubQ) for PI patients. Most often IV infusions are given every 3 or 4 weeks, whereas SubQ infusions are given every week. You and your healthcare provider will decide which route of administration is best for you. Most of the time Ig SubQ infusions are given at home by patients or caregivers after they have been trained by a healthcare professional. Intravenous Ig infusions are given in a hospital, infusion center, or at home by a nurse.1

Who should not use GAMMAGARD LIQUID?

Do not use GAMMAGARD LIQUID if you have a known history of a severe allergic reaction to immune globulin or other blood products. If you have such a history, discuss this with your healthcare provider to determine if GAMMAGARD LIQUID can be given to you.

Tell your healthcare provider if you have a condition called selective (or severe) immunoglobulin A (IgA) deficiency.

What should I avoid while taking GAMMAGARD LIQUID?

GAMMAGARD LIQUID can make vaccines (like measles/mumps/rubella or chickenpox vaccines) not work as well for you. Before you get any vaccines, tell your healthcare provider (HCP) that you take GAMMAGARD LIQUID.

Tell your HCP if you are pregnant, or plan to become pregnant, or if you are nursing.

What are the possible or reasonably likely side effects of GAMMAGARD LIQUID?

GAMMAGARD LIQUID can cause serious side effects. If any of the following problems occur after starting GAMMAGARD LIQUID, stop the infusion immediately and contact your HCP or call emergency services:

  • Hives, swelling in the mouth or throat, itching, trouble breathing, wheezing, fainting or dizziness. These could be signs of a serious allergic reaction.
  • Bad headache with nausea, vomiting, stiff neck, fever, and sensitivity to light. These could be signs of irritation and swelling of the lining around your brain.
  • Reduced urination, sudden weight gain, or swelling in your legs. These could be signs of a kidney problem.
  • Pain, swelling, warmth, redness, or a lump in your legs or arms. These could be signs of a blood clot.
  • Brown or red urine, fast heart rate, yellow skin or eyes. These could be signs of a liver or blood problem.
  • Chest pain or trouble breathing, or blue lips or extremities. These could be signs of a serious heart or lung problem.
  • Fever over 100°F. This could be a sign of an infection.

The following one or more possible reactions may occur at the site of infusion of GAMMAGARD LIQUID for PI, generally go away within a few hours, and are less likely after the first few infusions:

  • Mild or moderate pain
  • Swelling
  • Itching
  • Redness
  • Bruising
  • Warmth

During the infusion of GAMMAGARD LIQUID for PI, look out for the first signs of the following common side effects:

  • Headache
  • Migraine
  • Fever
  • Fatigue
  • Itching
  • Rashes/hives
  • Cough
  • Chest pain/tightness
  • Chills/shaking chills
  • Dizziness
  • Nausea/vomiting
  • Faster heart rate
  • Upper abdominal pain
  • Increased blood pressure
  • Muscle cramps
  • Sore throat

These are not all the possible side effects.
Talk to your HCP about any side effect that bothers you or that does not go away.

IV and SubQ Administration FAQ

How will I know if IV or SubQ is right for me?

You and your healthcare provider will make this choice based on your medical and personal needs. You can learn about the characteristics of IV and SubQ and download a chart explaining the two routes of administration in our section on choosing what's best for you.

What kind of training will I receive for SubQ administration? Is there review material available if I forget or just need a refresher?

Your nurse will show you how to administer SubQ infusions so that you feel comfortable with the steps to administer your infusion. You can also request educational materials on subcutaneous administration of GAMMAGARD LIQUID treatment. For more information, visit our support page.

Are there any special considerations for giving SubQ Ig to children?

GAMMAGARD LIQUID is used to treat PI in people 2 years and older. Your doctor will determine the right dose based on weight and Ig levels.1

Is traveling with supplies an issue?

Traveling with SubQ supplies is possible; however, it may require a bit more planning and coordination. Discuss any travel plans with your doctor.

Insurance FAQ

Do insurance plans cover SubQ the same as IV?

Contact your health insurance provider for information.

Is there financial support for treatment?

Visit our support page to learn more.

Gammagard Liquid MyIgCoPayCard Program Terms and Conditions

This manufacturer's coupon program is not valid for prescriptions reimbursed, in whole or in part, by Medicaid, Medicare, Medigap, VA, DoD, TRICARE, or any other federal or state healthcare programs, including state pharmaceutical assistance programs, and where prohibited by the health insurance provider or by law

Shire's MyIgCoPayCard program provides a maximum total benefit of $5,000 for eligible out-of-pocket costs and expires 12 months from date of activation. Eligible costs include deductible, copayment, and co-insurance costs for eligible Shire IG (Immunoglobulin) products. Non-medication expenses, such as ancillary supplies or administration-related costs, are not eligible.

To be eligible, patients must: 1. be starting or receiving treatment with (and have current prescription for) an eligible Shire IG product with an ICD-10 for a diagnosis of Primary Immunodeficiency; and 2. have commercial insurance that covers medication costs for prescribed Shire IG product and allows for CoPay assistance; and 3. be two (2) years old or older.

Acceptance of this offer must be consistent with the terms of benefits provided by patient's health insurance provider.

Offer limited to one card per person and may not be combined with any other coupon, discount, prescription savings card, rebate, free trial, patient assistance, or other offer.

This program is only valid for residents of the United States.

Shire reserves the right to change or discontinue this program at any time without notice.

This is not health insurance.


Add to patient instructions:

If your insurance situation changes, it is your responsibility to notify MyIgSource's CoPay assistance program.

© 2017 Shire. All rights reserved.

SHIRE and the Shire Logo are registered trademarks of Shire Pharmaceutical Holdings Ireland Limited or its affiliates. Gammagard Liquid is a trademark or registered trademark of Baxalta Incorporated, a wholly owned, indirect subsidiary of Shire plc.

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Please expand for Indication and Important Safety Information.


What is the most important information that I should know about GAMMAGARD LIQUID?

GAMMAGARD LIQUID can cause the following serious reactions: severe allergic reactions causing difficulty in breathing or skin rashes; decreased kidney function or kidney failure; blood clots in the heart, brain, lungs or elsewhere in the body; severe headache, drowsiness, fever, painful eye movements, or nausea and vomiting; dark colored urine, swelling, fatigue, or difficulty breathing.