What is GAMMAGARD LIQUID treatment?

GAMMAGARD LIQUID is a ready-to-use liquid medicine that contains immunoglobulin (Ig) antibodies, which protect the body against infection. These antibodies, collected from healthy people, replace the missing antibodies in PI patients.

GAMMAGARD LIQUID treatment is used to treat patients with primary immunodeficiency (PI) diseases. There are many forms of PI. The most common types of PI result in an inability to make a very important type of protein called antibodies, which help the body fight off infections from bacteria or viruses. GAMMAGARD LIQUID is made from human plasma that is donated by healthy people. It may carry a risk of transmitting viruses.1

To learn more, visit our GAMMAGARD LIQUID section.

How is GAMMAGARD LIQUID treatment administered?

GAMMAGARD LIQUID treatment can be administered into a vein (intravenously or IV) or under the skin (subcutaneously or SubQ) for PI patients only. Most often IV infusions are given every 3 or 4 weeks, whereas SubQ infusions are given every week. You and your healthcare provider will decide which route of administration is best for you. Most of the time Ig SubQ infusions are given at home by patients or caregivers. Intravenous Ig infusions are given in a hospital, infusion center or at home by a nurse.1

What are the side effects associated with GAMMAGARD LIQUID treatment?

See GAMMAGARD LIQUID IV side effects and SubQ side effects. These generally go away within a few hours, and may possibly be reduced after the first few infusions. Call your doctor or emergency services if you have a serious side effect occur.1

What can I do to reduce the risk of side effects?

The following conditions can increase the risk of side effects. You should tell your healthcare provider if you:1

  • Have selective IgA deficiency or a history of severe allergic reactions to immunoglobulin (Ig) or other blood products
  • Have or had any kidney, liver, or heart problems or history of blood clots
  • Are dehydrated
  • Have any bruising, inflammation (irritation), or infection of the skin
  • Are pregnant, become pregnant, or are nursing

Who should not be treated with GAMMAGARD LIQUID?

Some patients with a history of selective IgA deficiency or a history of a severe allergic reaction to Ig or other blood products may not be able to receive further treatment with GAMMAGARD LIQUID. If you have such a history, discuss this with your healthcare provider to determine if GAMMAGARD LIQUID can be safely administered to you.1

IV and SubQ Administration FAQ

How will I know if IV or SubQ is right for me?

You and your healthcare provider will make this choice based on your medical and personal needs. You can learn about the benefits of IV and SubQ and download a chart comparing the two routes of administration in our section on choosing what's best for you.

What kind of training will I receive? Is there review material available if I forget or just need a refresher?

Your nurse will show you how to administer SubQ infusions so that you feel comfortable with the steps to administer your infusion. You can also request educational materials on subcutaneous administration of GAMMAGARD LIQUID treatment. These include an infusion mat, a step-by-step guide to infusing, and a training DVD with both the adult and pediatric perspective. Call 1-855-250-5111 to order yours.

Are there any special considerations for giving SubQ Ig to children?

GAMMAGARD LIQUID is indicated for the treatment of PI in adult and pediatric patients two years of age or older. For patients under 40 kg (88 lbs), the maximum volume per site (20 mL/site) and maximum infusion rate (20 mL/hr/site) are less than for patients over 40 kg (30 mL/site and 30 mL/hr/site, respectively).1

Is traveling with supplies an issue?

Traveling with SubQ supplies is possible. It simply requires a bit more planning and coordination. For more information about traveling, please visit our Travel page. To order or learn more about the SubQ Travel Kit, call 1-855-250-5111 or visit the Program Enrollment.

Insurance and Support FAQ

Do insurance plans cover SubQ the same as IV?

Contact your health insurance provider for information.

Is there financial support for treatment?

A MyIgSource specialist is available by phone to answer your questions and can assist you.
Call 1-855-250-5111 to learn more.

Are there any resources available for patients receiving Ig infusions?

Shire offers a number of educational resources and services that may be helpful to primary immunodeficiency (PI) patients and caregivers.

To get access to experienced Patient and Nurse Advocates, useful tools, and up-to-date information, join MyIgSource, or call us at 1-855-250-5111.

Find Support

MyIgSource is here for you.
Call 1-855-250-5111, or enroll online.

Reference: 1. GAMMAGARD LIQUID [Immune Globulin Infusion (Human)] 10% [Prescribing Information]. Westlake Village, CA: Baxalta US Inc.


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Gammagard Liquid MyIgCoPayCard Program Terms and Conditions

This manufacturer's coupon program is not valid for prescriptions reimbursed, in whole or in part, by Medicaid, Medicare, Medigap, VA, DoD, TRICARE, or any other federal or state healthcare programs, including state pharmaceutical assistance programs, and where prohibited by the health insurance provider or by law

Shire's MyIgCoPayCard program provides a maximum total benefit of $5,000 for eligible out-of-pocket costs and expires 12 months from date of activation. Eligible costs include deductible, copayment, and co-insurance costs for eligible Shire IG (Immunoglobulin) products. Non-medication expenses, such as ancillary supplies or administration-related costs, are not eligible.

To be eligible, patients must: 1. be starting or receiving treatment with (and have current prescription for) an eligible Shire IG product with an ICD-10 for a diagnosis of Primary Immunodeficiency; and 2. have commercial insurance that covers medication costs for prescribed Shire IG product and allows for CoPay assistance; and 3. be two (2) years old or older.

Acceptance of this offer must be consistent with the terms of benefits provided by patient's health insurance provider.

Offer limited to one card per person and may not be combined with any other coupon, discount, prescription savings card, rebate, free trial, patient assistance, or other offer.

This program is only valid for residents of the United States.

Shire reserves the right to change or discontinue this program at any time without notice.

This is not health insurance.


Add to patient instructions:

If your insurance situation changes, it is your responsibility to notify MyIgSource's CoPay assistance program.

© 2017 Shire. All rights reserved.

SHIRE and the Shire Logo are registered trademarks of Shire Pharmaceutical Holdings Ireland Limited or its affiliates. Gammagard Liquid is a trademark or registered trademark of Baxalta Incorporated, a wholly owned, indirect subsidiary of Shire plc.

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Please expand for Indication and Important Safety Information.

Selected Important Safety Information for GAMMAGARD LIQUID
  • GAMMAGARD LIQUID can cause decreased kidney function or kidney failure, blood clots in the heart, brain, lungs or elsewhere in the body. Call your healthcare professional or go to your emergency department right away if you have: Reduced urination, sudden weight gain, or swelling in your legs. These could be signs of a kidney problem. Pain, swelling, warmth, redness, or a lump in your legs or arms. These could be signs of a blood clot.
  • Do not take GAMMAGARD LIQUID if you have a known history of a severe allergic reaction to IgG or other blood products.