What is GAMMAGARD LIQUID treatment?

GAMMAGARD LIQUID is a ready-to-use liquid medicine that contains immunoglobulin (Ig) antibodies, which may protect the body against infection. These antibodies, collected from healthy people, replace the missing antibodies in PI patients.

GAMMAGARD LIQUID treatment is used to treat patients with primary immunodeficiency (PI) diseases. There are many forms of PI. The most common types of PI result in an inability to make a very important type of protein called antibodies, which help the body fight off infections from bacteria or viruses. GAMMAGARD LIQUID is made from human plasma that is donated by healthy people. It may carry a risk of transmitting viruses.

To learn more, visit our GAMMAGARD LIQUID section.

How is GAMMAGARD LIQUID Treatment administered?

GAMMAGARD LIQUID treatment can be administered into a vein (intravenously or IV) or under the skin (subcutaneously or SubQ) for PI patients only. Most often IV infusions are given every 3 or 4 weeks, whereas SubQ infusions are given every week. You and your healthcare provider will decide which route of administration is best for you. Most of the time Ig SubQ infusions are given at home by patients or caregivers. Intravenous Ig infusions are given in a hospital, infusion center or at home by a nurse.

What are the risks associated with SubQ infusions of

See GAMMAGARD LIQUID IV side effects and SubQ side effects. These generally go away within a few hours, and may possibly be reduced after the first few infusions.

What can I do to reduce the risk of side effects?

The following conditions can increase the risk of side effects. You should tell your healthcare provider if you:

  • Have IgA deficiency or a history of severe allergic reactions to immunoglobulin (Ig) or other blood products
  • Have or had any kidney, liver, or heart problems or history of blood clots
  • Are dehydrated
  • Have any bruising, inflammation (irritation), or infection of the skin
  • Are pregnant, become pregnant, or are nursing

Who should not be treated with GAMMAGARD LIQUID?

Some patients with a history of IgA deficiency or a history of a severe allergic reaction to Ig or other blood products may not be able to receive further treatment with Ig, including GAMMAGARD LIQUID. If you have such a history, discuss this with your healthcare provider to determine if GAMMAGARD LIQUID can be safely administered to you.

IV and SubQ Administration FAQ

How will I know if IV or SubQ is right for me?

You and your healthcare provider will make this choice based on your medical and personal needs. You can learn about the benefits of IV and SubQ and download a chart comparing the two routes of administration in our section on choosing what's best for you.

What kind of training will I receive? Is there review material available if I forget or just need a refresher?

Your nurse will show you how to administer SubQ infusions so that you feel comfortable with the procedure. You can also request educational materials on subcutaneous administration of GAMMAGARD LIQUID treatment. These include an infusion mat, a step-by-step guide to infusing, and a training DVD with both the adult and pediatric perspective. Call 1-855-250-5111 to order yours.

Are there any special considerations for giving SubQ Ig to children?

GAMMAGARD LIQUID is indicated for the treatment of PI in adult and pediatric patients two years of age or older. For patients under 40 kg (88 lbs), the maximum volume per site (20 mL/site) and maximum infusion rate (20 mL/hr/site) are less than for patients over 40 kg (30 mL/site and 30 mL/hr/site, respectively).

Is traveling with supplies an issue?

Traveling with SubQ supplies is possible. It simply requires a bit more planning and coordination. For more information about traveling, please visit our Travel page. To order or learn more about the SubQ Travel Kit, call 1-855-250-5111 or visit the Program Enrollment.

Insurance and Support FAQ

Do insurance plans cover SubQ the same as IV?

Contact your health insurance provider for information.

Is there financial support for treatment?

A MyIgSource specialist is available by phone to answer your questions and
can assist you with financial assistance regarding your treatment.
Call 1-855-250-5111 to learn more.

Are there any resources available for patients receiving Ig infusions?

Shire offers a number of educational resources and services that may be helpful to primary immunodeficiency (PI) patients and caregivers.

To get access to experienced Patient and Nurse Advocates, useful tools, and up-to-date information, join MyIgSource, or call us at 1-855-250-5111.

Find Support

MyIgSource is here for you.
Call 1-855-250-5111, or enroll online.


  • Sign up to get access to experienced Patient and Nurse Advocates, insurance and financial support, useful tools, and more.
    Enroll Now
  • Ask an Advocate Questions about PI or PI treatments? Our trained Patient and Nurse Advocates can help, and asking your question is easy with our Ask An Advocate feature.
    Start Getting Answers
  • Insurance Questions? MyIgSource is available by phone to answer your questions and can assist you with insurance information regarding your treatment. Call 1-855-250-5111 to learn more.
    See More Information

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Terms and Conditions

Patient instructions

  1. By using this coupon, you are certifying that:
  2. 1) You meet the eligibility criteria and have read and agree to the terms and conditions of this manufacturer coupon program;
  3. 2) You will not, at any time, submit any costs for the product dispensed pursuant to this coupon to any government healthcare program for reimbursement;
  4. 3) You are permitting your personal information, including name, address, phone number, email address, and information related to health insurance and treatment, to be shared with Shire and companies working with Shire for the purpose of administering this program; and
  5. 4) You will notify your health insurance provider or other third-party payer of the use of this coupon if required to do so.
  6. If your insurance situation changes it is your responsibility to notify Shire's MyIgCoPayCard program.
  7. For questions about this program, patients and caregivers can call MyIgSource at (855) 250-5111.

Pharmacy instructions

  1. By submitting a claim for reimbursement pursuant to this manufacturer coupon program, the Pharmacy represents and warrants that:
  2. 1) It has dispensed GAMMAGARD LIQUID treatment to an eligible patient and in accordance with the terms and conditions of this program and the accompanying prescription;
  3. 2) Its participation in this program is consistent with all applicable laws and any obligations, including its contract with the applicable payer;
  4. 3) If the patient's insurance situation changes, it will notify Shire immediately by contacting the MyIgCoPayCard program;
  5. 4) It will report coupon assistance received to payers if so required; and
  6. 5) The entire benefit amount received will go to eligible expenses and it will not retain any portion of the benefit as payment to it for administration or ineligible expenses.
  7. For questions regarding processing, claim transmission, patient eligibility, or other issues, pharmacists can call the MyIgCoPayCard program directly at (855) 217-1615.