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Is IV or SC Administration Right For My PI Patient?

With GAMMAGARD LIQUID [Immune Globulin Infusion (Human)] 10%, you can choose either intravenous (IV) or subcutaneous (SC) infusion. The chart below lists some key things to consider when choosing an IgG route of administration for your patients.

Intravenous IgG Treatment (IV) Subcutaneous IgG Treatment (SC)
Infuses IgG antibodies directly into the bloodstream through a vein.1 Infuses IgG antibodies under the skin in the fatty tissue of abdomen, thighs, upper arms or lower back, not directly into the bloodstream.1,2
Given every 3 to 4 weeks.2 Given once a week.2
Infusion time will vary from patient to patient. Infusion time will vary from patient to patient.
Infusion rate varies by brand. For instance, GAMMAGARD LIQUID can be infused at 0.5 mL/kg/hr up to a maximum of 5 mL/kg/hr as tolerated.2 Infusion rate varies by brand. For instance, GAMMAGARD LIQUID [Immune Globulin Infusion (Human)] 10% can be infused at the following rates:2
  • Patients 40 kg (88 lbs) and greater: Initial infusion rate is 20 mL/hr/site, and maintenance 20 to 30 mL/hr/site as tolerated.
  • Patients under 40 kg (88 lbs): Initial infusion rate is 15 mL/hr/site, and maintenance 15 to 20 mL/hr/site as tolerated.
Can give the total dose of IgG in one infusion site.1 Total dose can be given in multiple infusion sites, not to exceed 8.2
Can be given in the following settings: hospital, physician office, or home with a nurse.1 Can be done at home, and should be done with an infusion partner.2
Usually given by a nurse. Can be self-infused after training by a qualified healthcare professional.3 Patients can only begin self-infusion after they have received instruction and are comfortable that they can perform all of the steps on their own.
Need to schedule recurring appointments. Nurse will encourage persistence and dedication. Need to be committed to self-treatment and closely follow infusion schedule.3


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Guide for Patient/Doctor Discussion

Our discussion guide, "GAMMAGARD LIQUID – IV or SC Administration: Which one is right for you?" can help your patients in discussing their options.

 Download Discussion Guide

 Download Full Prescribing Information


Ask a Patient Advocate

Our Patient Advocates are actual PI patients or caregivers, and your patients can call them to talk through their administration options.

Call 1-855-250-5111.

References: 1. Blaese RM, Bonilla FA, Stiehm ER, Younger ME, eds. Patient & Family Handbook for Primary Immunodeficiency Diseases. 5th ed. Towson, MD: Immune Deficiency Foundation; 2013. 2. GAMMAGARD LIQUID [Immune Globulin Infusion (Human)] 10% [Prescribing Information]. Westlake Village, CA: Baxter Healthcare Corporation. April 2014. 3. Berger M. Subcutaneous IgG Therapy in Immune Deficiency Diseases. Clinical Focus on Primary Immune Deficiencies 13. Towson, MD: Primary Immune Deficiency Foundation; 2008.


  • Your patients can get access to experienced Patient and Nurse Advocates, insurance and financial support, useful tools, and more.
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  • Ask a Patient Advocate Our Patient Advocates are actual PI patients or caregivers, and your patients can call them to talk through their administration options.

    Call 1-855-250-5111

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