• What is Primary Immunodeficiency (PI)?

    Primary Immunodeficiency (PI) describes a group of more than 200 disorders1. PI involves inherent defects in the immune system, that may cause an increased susceptibility to infections.2,3

    References: 1. Al-Herz W, Bousfiha A, Casanova JL, et al. Primary immunodeficiency diseases. An update on the classification from the International Union of Immunological Societies Expert Committee for Primary Immunodeficiency. Front Immunol. 2014;5(162):1-33. 2. Boyle JM, Buckley RH. Population prevalence of diagnosed primary immunodeficiency diseases in the United States. J Clin Immunol. 2007;27(5):497-502. 3. National Institute of Child Health & Human Development. Primary Immunodeficiency: when the body's defenses are missing. http://nichd.nih.gov/publications/pubs/primary_immuno.cfm?renderforprint=1. Updated April 7, 2008. Accessed May 17, 2013.

    • More About PI

      Get more background on primary immunodeficiency (PI), including different types and prevalence.
      More information
    • Diagnosing and Treating PI

      Learn about the barriers to diagnosis, how to evaluate your patient for PI, and treatment.
      What to know
    • Additional PI Resources

      Helpful resources for additional information about PI.
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